MBI035 - ASPARTATE AMINOTRANSFERASE (AST/SGOT), SERUM Detail

Aspartate aminotransferase (AST) is an intracellular enzyme that plays a key role in amino acid metabolism.

Description

Aspartate aminotransferase catalyzes the reversible transfer of an amino group from aspartate to α-ketoglutarate, producing oxaloacetate and glutamate. This reaction is important for protein metabolism and for linking amino acid metabolism with the citric acid (Krebs) cycle.

AST is widely distributed in body tissues, with high concentrations in the liver, heart, skeletal muscles, kidneys, brain, and red blood cells. Because it is present inside cells, AST is released into the bloodstream when these tissues are damaged or inflamed.

Clinical significance

AST is commonly measured in blood tests to help detect and monitor liver disease and other tissue injuries. Elevated AST levels may be seen in:

• Acute and chronic liver diseases (hepatitis, cirrhosis)

• Myocardial infarction

• Muscle injury or muscle disorders

• Hemolysis

Normal range

Serum AST levels are usually 8–40 U/L, depending on the laboratory.

In summary, AST is an important diagnostic enzyme used to assess liver function and tissue damage.